Auntie Mame: An Irreverent Escapade is a 1955 novel by American author Patrick Dennis chronicling the madcap adventures of a boy, Patrick, growing up as the ward of his Aunt Mame Dennis, the sister of his dead father.

The book is often described as having been inspired by Dennis' real-life eccentric aunt, Marion Tanner, whose life and outlook mirrored those of Mame, but Dennis denied the connection. The novel was a runaway bestseller, setting records on the New York Times bestseller list, with more than 2 million copies in print during its initial publication. It became the basis of a stage play, a film, a stage musical, and a film musical.

In 1958, Dennis wrote a sequel titled Around the World with Auntie Mame.